What Do You Stand For? Standup2Cancer Tonight At 8:00 P.M. E.T./P.T., 7:00 P.M. C.T.

This year, approximately 565,650 Americans are expected to die of cancer — that’s more than 1,500 people a day. … Ovarian cancer causes more deaths than any other cancer of the female reproductive system. … In an unprecedented television event, NBC, ABC, and CBS will simultaneously devote 1 hour of commercial-free prime time to raise funds for the fight against cancer under an initiative called “Standup2cancer.”

What Do You Stand For?

  • This year, approximately 565,650 Americans are expected to die of cancer — that’s more than 1,500 people a day.
  • Cancer is the second most common cause of death in the US, exceeded only by heart disease. In the US, cancer accounts for 1 of every 4 deaths.
  • The NIH estimate overall costs of cancer in 2007 at $219.2 billion:
    • $89.0 billion for direct medical costs;
    • $18.2 billion for lost productivity due to illness; and
    • $112.0 billion for lost productivity due to premature death.
  • Ovarian Cancer can afflict adolescent, young adult, and mature women, although the risk of disease increases with age and peaks in the late 70s. Pregnancy and the long-term use of oral contraceptives reduce the risk of developing ovarian cancer.
  • Women who have had breast cancer, or who have a family history of breast cancer or ovarian cancer may have increased risk. Inherited mutations in BRCA1 or BRCA2 genes increase risk. Another genetic syndrome, hereditary nonpolyposis colon cancer, has also been associated with endometrial and ovarian cancer.
  • Ovarian cancer incidence rates are highest in Western industrialized countries.
  • Ovarian cancer accounts for about 3% of all cancers among women and ranks #2 among gynecologic cancers.
  • An estimated 21,650 new ovarian cancer cases are expected in the U.S. in 2008.
  • An estimated 15,520 ovarian cancer deaths are expected in 2008.
  • Ovarian cancer causes more deaths than any other cancer of the female reproductive system.
  • Ovarian cancer is not a “silent” disease; it is a “subtle” disease. Recent studies indicate that some women may experience persistent, nonspecific symptoms, such as (i) bloating, (ii) pelvic or abdominal pain, (iii) difficulty eating or feeling full quickly, or (iv) urinary urgency or frequency. Women who experience such symptoms daily for more than a few weeks should seek prompt medical evaluation. (To learn more about the warning signs and symptoms of ovarian cancer, CLICK HERE).
  • There is no reliable screening test for the detection of early stage ovarian cancer. Pelvic examination only occasionally detects ovarian cancer, generally when the disease is advanced. However, the combination of a thorough pelvic exam, transvaginal ultrasound, and a blood test for the tumor marker CA125 may be offered to women who are at high risk of ovarian cancer and to women who have persistent, unexplained symptoms like those listed above.
  • If diagnosed at the localized stage, the 5-year ovarian cancer survival rate is 92%; however, only about 19% of all cases are detected at this stage, usually fortuitously during another medical procedure.
  • For women with regional and distant metastatic disease, the 5-year ovarian cancer survival rates are 71% and 30%, respectively. The 10-year relative survival rate for all stages combined is 38%.
  • During 1987-2004, ovarian cancer incidence declined at a rate of 0.9% per year.

Sources: Cancer Facts & Figures 2008, American Cancer Society (Adobe Reader PDF); There Are Many Ways To Fight Cancer. Cutting Funding For Research Isn’t One of Them, by Paul Cacciatore, Libby’s H*O*P*E* post, June 10, 2008.

Tonight, over 50 of the most renowned personalities in TV, film, sports and music will come together to make history. In an unprecedented television event, NBC, ABC, and CBS will simultaneously devote 1 hour of commercial-free prime time to raise funds for the fight against cancer under an initiative called “Standup2cancer.” In May, Libby’s H*O*P*E*™ covered the opening of the Standup2cancer initiative. [May 30, 2008].

A spectacular line up of talent including Jennifer Aniston, James Taylor, Scarlett Johansson, Meryl Streep, David Cook, Christina Applegate, Lance Armstrong, Jack Black, Kirsten Dunst, Charles Barkley, America Ferrera, Halle Berry, Hilary Swank, Forrest Whitaker, Jimmy Fallon, Keanu Reeves will make personal appearances on the show. These celebrities and more will educate you, move you and entertain you. They will also be on hand to answer your calls in the celebrity phone bank.

To donate, CLICK HERE. The YouTube video below provides an explanation of how the public donations will be used.

SU2C: Where the Money Goes?

The premiere TV performance of “Just Stand Up” – the star studded charitable single in support of Stand Up To Cancer will be performed tonight by legendary recording artists Mariah Carey, Beyonce, Mary J. Blige, Rihanna, Fergie, Sheryl Crow, Miley Cyrus, Melissa Etheridge, Ashanti, Natasha Bedingfield, Keyshia Cole, Ciara, Leona Lewis, LeAnn Rimes, and Carrie Underwood.

Just Stand Up! – Standup2cancer


Stand Up To Cancer On Sept. 5th – This Is Where the End of Cancer Begins

“Stand Up To Cancer (www.standup2cancer.org), a new initiative to raise philanthropic dollars for accelerating ground-breaking research, launches today through an unprecedented collaboration uniting the major television networks, entertainment industry executives, celebrities and prominent leaders in cancer research and patient advocacy. ABC, CBS and NBC will donate one hour of simultaneous commercial-free primetime for a nationally televised fundraising event to air on September 5, 2008 (8:00 pm EDT and PDT), aimed at rallying the public around the goal of ending cancer’s reign as a leading cause of death. … Stand Up To Cancer’s innovative approach to research is designed to eliminate barriers that have traditionally inhibited creativity and collaboration by enabling the best and brightest investigators from leading institutions across the country and internationally to work together. These collaborative “Dream Teams” will pursue the most promising research, accelerating the discovery of new therapies for cancer patients and advancing efforts in cancer prevention research.Stand Up To Cancer monies will also be used for some high-risk, high-impact cancer research proposals, which are often not supported by conventional funding sources.”

Stand Up To Cancer (www.standup2cancer.org), a new initiative to raise philanthropic dollars for accelerating ground-breaking research, launches today through an unprecedented collaboration uniting the major television networks, entertainment industry executives, celebrities and prominent leaders in cancer research and patient advocacy. ABC, CBS and NBC will donate one hour of simultaneous commercial-free primetime for a nationally televised fundraising event to air on September 5, 2008 (8:00 pm EDT and PDT), aimed at rallying the public around the goal of ending cancer’s reign as a leading cause of death.

Network evening news anchors Charles Gibson, Katie Couric and Brian Williams will announce the initiative together during live appearances today on ABC’s “Good Morning America,” CBS’s “The Early Show,” and NBC’s “TODAY show.”

‘For people struggling with this disease, or those who will be diagnosed, scientific breakthroughs can be a matter of life or death — literally. We want everyone to know that they can make a difference in this fight,’ said Couric. ‘Television is a notoriously competitive business. For the three major broadcast networks to join forces is a wonderful example of the power of working together, and we’re very grateful to have the opportunity to reach people all over the country through this show.’

‘As a motion picture and television producer, I’ve learned how incredibly powerful these mediums can be in generating public discourse, sometimes almost overnight. Our goal with this initiative and TV show is to ‘tip’ the conversation in this country about cancer – to get people riled up, so they want to do something about the fact that it still takes so many lives,’ said Laura Ziskin, who will produce the September 5th broadcast. Ziskin is a cancer survivor. Her film credits include the Spider-Man trilogy, As Good As It Gets, and Pretty Woman, and she also produced the 74th and 79th Annual Academy Awards.

The Stand Up To Cancer special will feature live performances by legendary recording artists and stars from film and television who will perform as well as present filmed content giving viewers insight into cancer. Various screening tests will be demonstrated in novel and entertaining ways. ‘Katie, Charlie and Brian will report on potentially life-saving research, speaking with both patients and scientists. We hope to entertain you, educate you, move and inspire you,’ Ziskin said.

Stand Up To Cancer (SU2C) is a program of the Entertainment Industry Foundation (EIF), a 501(c)(3) charitable organization, and was established by a group of media, entertainment and philanthropic leaders, whose lives have all been affected by cancer in significant ways. Stand Up To Cancer is bringing industry resources — people, as well as mediums such as television and the web — to bear in the fight against cancer as never before.

The SU2C leadership team includes Katie Couric; the Entertainment Industry Foundation, represented by Board of Directors Chairperson Sherry Lansing (who is Founder of the Sherry Lansing Foundation) and CEO Lisa Paulsen; Laura Ziskin; the Noreen Fraser Foundation and its executives Noreen Fraser (who is also a cancer survivor), Woody Fraser, Rusty Robertson and Sue Schwartz; and nonprofit executive Ellen Ziffren.

‘The statistics are staggering,’ Gibson said. ‘Cancer claims one person every minute of every day in the United States. Every year in this country, it takes the lives of more than half a million people…worldwide, cancer kills more than six million people annually. There has been progress on both the research and awareness fronts; as a result, there are over ten million cancer survivors in the US today. More work urgently needs to be done so that more people will survive,’ he said.

‘Not only has cancer touched all of our media organizations in profound ways, but it has touched each of us personally. This extraordinary broadcast will serve a number of purposes – we’ll share vital information with our viewers and hopefully raise funds that are so critical in the fight against this insidious disease,’ said Williams.

New developments in the laboratory are revealing the way cancer begins, progresses and spreads. Stand Up To Cancer is founded on the belief that now, more than ever, there is sufficient knowledge of the basic science of cancer, and that the technologies are finally available to translate this knowledge into real advances in treatment and prevention. Today’s cancer scientists are on the verge of life-saving discoveries. But what they desperately need are the funds required to mount an all-out assault. Stand Up To Cancer is dedicated to providing this much needed new source of cancer research funding.

Co-Chair of the Disney Media Networks and President of the Disney-ABC Television Group Anne Sweeney, CBS Corporation President and Chief Executive Officer Leslie Moonves, and NBC Universal President and Chief Executive Officer Jeff Zucker commented on their companies’ decisions to collaborate.

‘Everyone in our country has been touched by cancer in some way, shape or form. The thought that we could, in one hour of television, make a true difference in the fight against this disease was both exciting and inspiring,’ Sweeney said.

‘Television is a uniquely powerful medium and the networks joining forces offer an unparalleled opportunity to communicate loud and clear that we all have a stake in the fight against cancer,’ said Moonves. ‘Through the unity of broadcasters, entertainers and cancer groups alike, and the giving spirit of the audience at home, this television event has the potential to make a profound impact on our society’s ability to understand and battle this terrible disease.’

‘We’ve gone to the moon and pioneered a technology that revolutionized the way the world communicates. Applying that same innovation and commitment, scientists are on the cusp of making enormous strides in their efforts to combat cancer, but they need additional funding to do that. Through Stand Up To Cancer, and the September 5th broadcast, people all over the country can help,’ said Zucker, who is a cancer survivor.

AN INNOVATIVE RESEARCH MODEL

Stand Up To Cancer’s innovative approach to research is designed to eliminate barriers that have traditionally inhibited creativity and collaboration by enabling the best and brightest investigators from leading institutions across the country and internationally to work together. These collaborative “Dream Teams” will pursue the most promising research, accelerating the discovery of new therapies for cancer patients and advancing efforts in cancer prevention research. Stand Up To Cancer monies will also be used for some high-risk, high-impact cancer research proposals, which are often not supported by conventional funding sources.

The American Association for Cancer Research (AACR) will conduct expert scientific review of the research projects and administer funds raised through the initiative under the direction of a Scientific Advisory Committee. Nobel Laureate Phillip A. Sharp, Ph.D., Institute Professor at the Massachusetts Institute of Technology and the David H. Koch Institute for Integrative Cancer Research at MIT chairs the Committee, which includes highly accomplished clinical investigators, senior laboratory researchers and physician-scientists. ‘This project has tremendous potential to change the face of cancer research,’ said Sharp. ‘Our goal is to rapidly move new research discoveries out of the lab and into the clinic to save lives from cancer.’

‘I am pleased that AACR is a partner in the Stand Up To Cancer initiative,’ said Raymond N. DuBois, M.D., Ph.D., AACR President and Provost and Executive Vice President at M. D. Anderson Cancer Center. ‘Stand Up To Cancer model is distinctive because it emphasizes collaboration among scientists and will accelerate translational research on the verge of breakthroughs as well as provide an additional revenue stream to encourage novel, high-risk proposals that have great potential in making inroads against cancer.’

A Stand Up To Cancer Advocate Advisory Council is being formed, and will include leaders from approximately 25 organizations. Additionally, representatives from the advocacy community will work side-by-side with the scientists on the “Dream Teams,” so the perspectives of the patients and survivors they represent will be integrated into the direction of the research.

INITIATIVE DETAILS

In addition to the nationally televised network fundraising event, other key elements of the initiative include:

Standup2cancer — With both interactive applications and rich content, the SU2C web site will foster an online community for everyone affected by cancer, utilizing the same approach as the televised special: it will move, educate and even entertain users. Features include: The Constellation: For a dollar donation or more, users can launch a star in honor of anyone who has received a cancer diagnosis. The Stand: An interactive facebook application to illustrate that the ‘cancer community’ encompasses everyone and that we are all connected by this disease. SUTV: Features video segments rich in scientific and research information, as well as ones that confront the personal and human side of cancer’s impact. SU2C Magazine: Offers seven sections of diverse content written by leading voices in every field.

• Public Service Announcement (PSA) Campaign – A series of TV, radio and print PSAs featuring celebrities and members of the general public to mobilize support for the campaign will begin to air and appear in publications soon.

‘I have lost beloved family members and friends to this dreaded disease,’ said Sherry Lansing. ‘Sometimes I feel as if cancer is an epidemic that will never end. But then I am reminded of diseases such as tuberculosis, small pox and polio that used to cause fear… and then I know that just like those other diseases, cancer can and will be defeated, too.’

Major League Baseball was the first donor to contribute to Stand Up To Cancer. ‘This initiative has presented an historic and unique plan to fight this deadly disease, and it is a privilege for me and Major League Baseball to join this magnificent effort,’ said Baseball Commissioner Allan H. (Bud) Selig. ‘We have pledged many of our valuable resources in an attempt to assist in every way we can.’

Many other leading organizations have joined in supporting its mission, including AARP, Alliance for Global Good, AOL, Condé Nast Media Group, Def Jam Recordings, Lee Jeans, The Paley Center for Media, Philips, Playphone, Revlon, Ronald Perelman, Saks Fifth Avenue, Stonyfield Farm, and Steve Tisch, as well as media partners Hearst Magazines, Los Angeles Times, The Meredith Publishing Group, The New York Times and Time Inc.

Cancer advocacy and support groups collaborating with Stand Up To Cancer include: The Lance Armstrong Foundation, American Cancer Society Cancer Action Network, Breastcancer.org, C-Change, CancerCare, Colon Cancer Alliance, C3: Colorectal Cancer Coalition, Friends of Cancer Research, Intercultural Cancer Council, Leukemia & Lymphoma Society, Lung Cancer Alliance, The Multiple Myeloma Research Foundation, National Breast Cancer Coalition, National Coalition for Cancer Survivorship, Pancreatic Cancer Action Network, The Prostate Cancer Foundation, Susan G. Komen for the Cure, The Wellness Community and others.

About AACR

The American Association for Cancer Research (AACR) is the oldest and largest scientific organization in the world focusing on every aspect of high-quality, innovative cancer research. Its reputation for scientific breadth and excellence attracts the premier researchers in the field. By accelerating the growth and spread of new knowledge about cancer, the AACR is on the front lines in the quest for the prevention and cure of cancer.

About the Entertainment Industry Foundation

The Entertainment Industry Foundation (EIF), as a leading charitable organization of the entertainment industry, has distributed hundreds of millions of dollars to support programs addressing critical health, education and social issues.

About the Noreen Fraser Foundation

The Noreen Fraser Foundation utilizes film, television and web technologies to raise money as well as to educate and raise awareness about women’s cancers. The funds raised will be used to provide large grants to uniquely qualified cancer researchers.

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Media Contacts:

Ketchum Global Media Network Nicholas Scibetta — 646.935.4067 or 917.873.5299 mobile nicholas.scibetta@ketchum.com

ABC Jeffrey Schneider — 212.456.3587 jeffrey.w.schneider@abc.com

Kevin Brockman — 818.460.6655 kevin.m.brockman@disney.com

CBS Sandy Genelius — 212.975.7525 smg@cbsnews.com

Phil Gonzales — 323.575.2028 phil.gonzales@tvc.cbs.com

NBC Allison Gollust — 212.664.3220 allison.gollust@nbcuni.com

Stand Up To Cancer Kathleen Lobb — 212.522.4278 klobb@eifoundation.org

AACR Staci Goldberg – 267.646.0616 staci.goldberg@aacr.org”

[Quoted Source: ABC, CBS, NBC ANNOUNCE HISTORIC COLLABORATION TO "STAND UP TO CANCER,Standup2cancer.com Press Release, May 28, 2008.]

Comment: In 1971, President Nixon “declared war on cancer.” Unfortunately, the technology and science of the 1970’s was simply not advanced enough to accomplish such a goal. The complexities of cancer are many including the following: (i) the area of “cancer” encompasses approximately 200 separate diseases, and (ii) the biological processes that allow cancer to thrive are nearly identical to those that allow a single cell, fertilized embryo to grow into a one trillion cell adult human. If you fast forward to this past decade, it is clear that current day technology and science is capable of achieving the short-term goal of holding cancer in check while pursuing the long-term goal of a cure. Discovery and identification of the human genome (Adobe Reader PDF document) in tandem with the mapping of biological “cellular pathways,” have produced highly successful advanced targeted cancer therapies such as Gleevec® and Herceptin®. The Human Genome Project identified approximately 20,500 genes in the human DNA sequence, and to date, that project fueled – in large part – the discovery of approximately 1,800 “disease genes” (Adobe Reader PDF Document). Our current ability to identify numerous genetic anomalies in cancer cells quickly, simultaneously and cost effectively allows for the targeting of such anomalies through pharmacological drug and/or gene therapy. Super computers allow scientist to generate the extensive bioinformatics necessary to produce complex models and analyze study data involving millions of permutations associated with 20,500 human genes, which hold approximately 3 billion pieces of DNA information. Although in its infancy, the use of “silencing RNA” (siRNA) to turn various genes on or off is making great strides toward controlling cancer in vitro and in vivo.

Human epigentics – another missing piece to the cancer puzzle – is the subject of the Human Epigenome Project, which is being conducted by the Human Epigenome Consortium. The Human Genome Project provided the blueprint for life, but the Human Epigenome Project will tell us how the human genome gets executed, as well as what determines when and where genes are switched on and off. The best example of epigenetics at work is the case of identical twins, where one twin is autistic while the other twin is normal. In this case, the genome DNA sequence of both twins is identical, but something else causes a change. That “something else” is represented by chemical modifications of genes that act as green or red traffic lights, which are superimposed on top of the DNA sequence or genome and tell the genes whether to be active or inactive. The study of these modifications-what they are, how they are laid down, and the processes that they control-is the field of research known as “epigenetics.” An “epigenome” is the description of these chemical modifications across the whole genome, but unlike the genome DNA sequence, each organism has multiple epigenomes-for example, in different cell types-that may change during its lifetime in response to environmental conditions or cues. And, knowing more about the human epigenome may provide clues as to what goes wrong in cancer and other diseases. Human Epigenome Project-Up and Running, Bradbury J.; PLoS Biol 1(3): e82 (2003).

The Stand Up to Cancer paradigm is truly groundbreaking. It is designed to “end run” bureaucratic obstacles to cancer control and cure discoveries. Through world-class private sector philanthropy, the medical, biological, genetic, and translational research necessary to tackle this ambitious goal will be carried out in a fully coordinated effort by the brightest scientific minds in the nation and around the world. Under the Stand Up To Cancer approach there will be accountability for results and oversight to guard against conflicts of interest. If you carefully review the names of those directly or indirectly associated with the Stand Up to Cancer organization, you will discover that they represent those individuals, scientists, and companies that had the greatest impact – through fundraising or science – on cancer therapy developments and discoveries over the past decade. I provide below the Stand Up To Cancer Public Service Announcement video, along with an additional video featuring the Stand Up To Cancer news coverage by CBS. To view additional Stand Up To Cancer videos featuring Katie Couric, Larry David, Sidney Poitier, Robert Bazell, Ben Teller & other celebrities who support the movement, click here.

What Can You Do?: Stand Up To Cancer invites donations in many forms. For a contribution of $1.00 or more, you can “create a star” as part of the Constellation program in the name of a cancer survivor or in memory of a family member or friend who lost the battle to cancer. On a larger scale, you can form a “private” team and request donations from family, friends, and co-workers. Alternatively, if you do not want to form a private team, consider making a donation to the “Choose H*O*P*E*” open team that was formed recently by the H*O*P*E*™ weblog or make a standalone donation. In the future, you will even be able to donate through your cell phone. Through any form of donation, you are making a difference in the fight against cancer!

Stand Up To Cancer Public Service Announcement

Notebook: Stand Up To Cancer on CBS News