Genetics

GENETICS

(incl. hereditary breast and ovarian cancer (HBOC) syndrome, Lynch syndrome (hereditary nonpolyposis colorectal cancer), genetic testing & genetic counseling)

Overview:

Talking Glossary of Genetic Terms, National Human Genome Research Institute, National Institutes of Health, 2009.

NCI Dictionary of Genetics Terms, National Cancer Institute.

Help Me Understand Genetics Handbook, U.S. National Library of Medicine, National Institute of Health, December 4, 2009.

Understanding Cancer Series: Cancer Genomics, Slide Presentation, National Cancer Institute, September 1, 2006.

Learn. Genetics™, Genetic Science Learning Center, The University of Utah, 2009.

Features of Inherited Cancer, Stanford Cancer Center.

Understanding Hereditary Cancer, Podcast, The University of Texas M.D. Anderson Cancer Center, 2009.

Am I At Risk For Hereditary Cancer?, Podcast, The University of Texas M.D. Anderson Cancer Center, 2009.

Genetics of Breast and Ovarian Cancer PDQ® (Health Professional Version), National Cancer Institute, December 4, 2009.

Understanding Cancer Series: Gene Testing, National Cancer Institute, September 1, 2006.

Cancer Genetics Overview PDQ® (Health Professional Version), National Cancer Institute, December 4, 2009.

The Genetics of Cancer, All About Cancer, Cancer.Net (an ASCO website), August 2009.

Genetics of Breast and Ovarian Cancer – Information for Health professionals — Dana-Farber Cancer Institute, September 9, 2007.

Hereditary Breast Ovarian Cancer Syndrome (BRCA1 / BRCA2), Standford Cancer Center.

Breast/Ovarian Cancer, GeneticHealth, December 12, 2001.

Breast and Ovarian Cancer: A Genomic Medicine Review; Wooster, R, Weber, BL.; New England Journal of Medicine 348(23):2339-2347 (June 5, 2003).

Hereditary Breast & Ovarian Cancer Syndrome, The University of Texas M.D. Anderson Cancer Center (Adobe Reader PDF Document).

Hereditary Cancer and Cancer Genetics, Facing Our Risk of Cancer Empowered (FORCE), 2008.

FORCE Brochures Re Cancer & Genetics

Red Flags for Hereditary Cancers, by Jane E. Brody, Health Section, New York Times, May 28, 2008.

The Genetics of Ovarian Cancer, All About Cancer, Gentics, Cancer.Net (an ASCO website), September 2008.

Genetic Risk Screening Questionnaires & Calculators:

BRCA Risk Calculator and Mutation Prevalence Tables; Spring 2006; Myriadtests.com. — Source: [“Clinical Characteristics of Individuals With Germline Mutations in BRCA1 and BRCA2: Analysis of 10,000 Individuals;” Frank, Deffenbaugh, Reid, Hulick, Ward, Lingenfelter, Gumpper, Scholl, Tavtigian, Pruss, Critchfield; Journal of Clinical Oncology, Vol 20, Issue 6 (March), 2002: 1480-1490 (Full Text).

Assess Your Risk of Genetic Breast/Ovarian Cancer (On-Line Personal Education and Risk Assessment [OPERA]),” MacMillan Cancer Support (formerly CancerBackup.org).

Breast Cancer Risk Assessment Tool,” National Cancer Institute.

Family History Cancer Risk Assessment: JamesLink,” The Ohio State University Comprehensive Cancer Center – James Cancer Hospital & Solove Research Institute.

Your Disease Risk – Ovarian Cancer,” Siteman Cancer Center, Barnes-Jewish Hospital, Washington University School of Medicine.

Hereditary Cancer Quiz,” Myriad Genetics Laboratories, Inc.

Hereditary cancer risk assessment tool,” Cancer Genetics Counseling Program, Aurora Health Care.

Family History: Resources & Tools,” National Office of Public Health Genomics, Centers for Disease Control (CDC).

Genetic Testing:

Genetic cancer risk assessment and counseling: recommendations of the National Society of Genetic Counselors,” Trepanier A. et. al., J Genet. Counsel 2004 Apr;13(2):83-114.

Clinical Considerations,” Genetic Risk Assessment and BRCA Mutation Testing for Breast and Ovarian Cancer Susceptibility Recommendation Statement, U.S. Preventive Services Task Force (USPSTF), Agency for Healthcare Research & Quality (AHRQ), U.S. Department of Health & Human Services, September 2005

“Genetic Testing,” Learning About Cancer, Cancer.Net, August 2006.

The Benefits of Genetic Testing,” Myriad Genetics Laboratories, Inc.

Fact Sheet on Genetic Testing for Breast and Ovarian Cancer Susceptibility” — National Office of Public Health Genomics, National Center For Disease Control (CDC), June 8, 2007.

American Society of Clinical Oncology Policy Statement Update: Genetic Testing for Cancer Susceptibility,” Journal of Clinical Oncology, Vol 21, Issue 12 (June), 2003: 2397-2406.

Genetic Testing for Breast and Ovarian Cancer Susceptibility: A Family Experience” by Marcia Van Riper, RN, PhD, June 6, 2004. — Medscape.com (registration is free).

Sharing Genetic Test Results With Your Family,” Learning About Cancer, Cancer.Net, August 2006.

Caution urged in choosing gene tests,” by Lauran Neergaard, Associated Press (Washington) Release, May 5, 2008.

Informed Medical Decisions website.

Genetic Counseling:

Elements of Cancer Genetics Risk Assessment and Counseling (PDQ®)(Health Professsional Version), National Cancer Institute, March 5, 2008.

What to Expect When Meeting With a Genetic Counselor,” Learning About Cancer, Cancer.Net, August 2006.

Cancer Genetics Services Directory Search,” National Cancer Institute.

National Society of Genetic Counselors, Inc. Search” — National Society of Genetic Counselors Inc.

How to Find a Genetic Counselor,” GeneticHealth, December 4, 2003.

Finding a Genetics Specialist,” FORCE: Facing Our Risk of Cancer Empowered, January 14, 2008.

Genetic Management & Risk Reduction:

Risk Management,” FORCE: Facing Our Risk of Cancer Empowered, January 14, 2008.

Reducing the Risk of Breast and Ovarian Cancer,” Myriad Genetics Laboratories.

Risk-reducing salpingo-oophorectomy for the prevention of BRCA1- and BRCA2-associated breast and gynecologic cancer: a multicenter, prospective study;” Kauff ND, Domchek SM, Friebel TM, Robson ME, Lee J, Garber JE, Isaacs C, Evans DG, Lynch H, Eeles RA, Neuhausen SL, Daly MB, Matloff E, Blum JL, Sabbatini P, Barakat RR, Hudis C, Norton L, Offit K, Rebbeck TR; Clinical Genetics and Gynecology Services, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 192, New York, NY 10021, USA. kauffn@mskcc.org; J Clin Oncol. 2008 Mar 10;26(8):1331-7.

Bilateral oophorectomy before 50 years of age is significantly associated with the metabolic syndrome and Framingham risk score: a controlled, population-based study (HUNT-2),” Dørum A et. al., Gynecol Oncol. 2008 Jun;109(3):377-83. Epub 2008 Apr 14.

Genetic Registries:

Gilda Radner Familial Ovarian Cancer Registry,” OvarianCancer.com.

Ovarian Cancer Whispers; New Registry Will Listen,” Oregon Ovarian Cancer Registry (OOCR), Oregon Health & Science University Press Release, May 15, 2008 (This registry is not limited to Oregonians).

Lynch syndrome (hereditary nonpolyposis colorectal cancer) – Women with Lynch syndrome have an increased lifetime risk for endometrial and ovarian cancer:

Gynecologic cancers associated with Lynch syndrome/HNPCC,” Schmeler KM et. al, Clin Transl Oncol. 2008 Jun;10(6):313-7.

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